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Herpangina is a febrile disease caused by coxsackieviruses and echoviruses. Beta streps are NEVER resistant to penicillin or amoxicillin. In particular, in one aspect the invention pertains to methods for using the novel substituted tetracycline compounds of the invention for regulating expression of a target nucleic acid sequence that is under transcriptional control of a tetracycline-responsive promoter element (TRE) in a cell of a subject.